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Australian researchers find hunger switch

Australian scientists have found how to switch hunger on and off using a molecule that targets the brain -- a discovery which could stop weight loss in terminally ill patients or produce weight loss in the morbidly obese.

The molecule, known as MIC-1, is produced by common cancers and targets receptors in the brain that switch off appetite. But Australian researchers found that by using antibodies against MIC-1 they were able to switch appetite back on.

When normal and obese mice were treated with MIC-1 they ate less and lost a lot of weight, suggesting that MIC-1 may also be used to treat severe obesity, said the Sydney researchers in a statement received on Tuesday.

"This work has given us a better understanding of the part of the brain that regulates appetite," said Herbert Herzog, director of neuroscience research at the Garvan Institute in Sydney.

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"Our bodies send complex chemical signals to our brains, which interpret them and send back responses, in this case eat or don't eat. Our research indicated that MIC-1 is a previously unrecognized molecule sending a don't eat signal to the brain," Herzog said.